Comprehensive Chromosome Screening (CCS) in Atlanta

Atlanta Center for Reproductive Medicine (ACRM), a CCRM network clinic, is pleased to offer comprehensive chromosomal screening (CCS) for patients undergoing in vitro fertilization (IVF). CCS evaluates all 23 pairs of human chromosomes in search of abnormalities (aneuploidy). Screening embryos in advance can help achieve higher implantation rates and fewer pregnancy losses, particularly for women 35 years or older, individuals with multiple failed IVF cycles or implantation failure, and couples with repeated miscarriages. An estimated 70% of early miscarriage is associated with a chromosomal abnormality in the fetus.

CCS testing is performed on a few cells biopsied from a 5 or 6 day old embryo called a blastocyst. The genetic material of the embryo is not altered in any way during CCS. During the time it takes to perform CCS, blastocysts are cryopreserved (frozen) using a quick freezing method called vitrification. Embryo survival after vitrification is extremely high, at greater than 98%.

After CCS testing, only embryos that have a normal number of chromosomes are selected for transfer.

Who Should Consider CCS?

CCS is not necessarily used by all infertility patients. Those who may benefit from CCS include the following:

  • Women 35 years of age or older
  • Women with a history of repeated miscarriage
  • Women with a previous pregnancy involving a chromosomally abnormal embryo
  • Women who have had multiple failed IVF cycles
  • Men with severe male factor infertility
  • Couples who elect for a single embryo transfer (SET)

Over 2,500 healthy babies and countless ongoing healthy pregnancies have resulted from the use of CCS.

Next–Generation Sequencing

Next-generation sequencing (NGS) is the latest technological breakthrough in pre-implantation genetic testing. NGS allows us to study all 23 pairs of chromosomes at a more comprehensive level and with deeper resolution. ACRM ’s CCS lab extensively validated the accuracy, reproducibility and reliability of this revolutionary new CCS NGS platform (VeriSeq™ by Illumina).

The CCS lab runs at the highest level of expertise with strict quality control and data analysis to enable the accurate CCS diagnosis of IVF embryos. As part of our ongoing commitment to excellence, they routinely reconfirm diagnosis on aneuploid embryos to better understand the incidence of chromosome abnormality.

Added Benefits of CCS

Waiting for CCS results and vitrifying the embryos has an added benefit to the patient. It offers some time for the patient’s body to return to a normal hormonal state after ovarian stimulation. Studies have shown that transferring embryos into a uterus that is in a more natural hormonal state enhances the likelihood of implantation by optimizing the synchronization between embryo and uterine lining and a healthier more comfortable pregnancy overall.

For more information regarding CCS and to schedule a consultation with one of our physicians, please call: 678.841.1089 or toll free 877.767.2276 or request an appointment here.

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